Katie Rudd, Ph.D., F.A.C.M.G
Assistant Professor
krudd@genetics.emory.edu
404.727.9486
Office 315B
Lab: 315
Whitehead Biomedical Research Building
615 Michael Street
Atlanta, GA 30322

PubMed search for Dr. Katie Rudd

Areas of Specialization/Research Interests:
Subtelomeres
Chromosome breakage
Chromosome biology
Genome evolution

Education:
2007     Fellowship in Medial Genetics, University of Washington, Seattle, WA
2005     Ph.D., Genetics, Case Western Reserve University, Cleveland, OH
1998     B.S., Biology, The College of William and Mary, Williamsburg, VA

Board Certification:
2007 Clinical Cytogenetics, American Board of Medical Genetics

Research Description:
The Rudd lab studies chromosome breakage mechanisms, focusing on breaks at the ends of chromosomes.  Subtelomeres are the terminal regions of chromosomes just proximal of telomere repeats.  Rearrangements at the ends of chromosomes can cause mental retardation or exist as normal copy number variants.  Subtelomeres are a unique part of the genome, subject to elevated frequencies of breaks in mitosis and meiosis.  In order to understand the mechanism of subtelomeric breaks, we are fine-mapping breakpoints using high-resolution array CGH.  We predict that certain subtelomeric sequences are predisposed to break and are subsequently repaired by non-homologous end-joining.  

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Selected Publications:
Rudd, M.K., Endicott, R.E., Friedman, C.F., Walker, M., Young, J.M., Osoegawa, K., Blakesley, R., de Jong, P., Green, E.D., and Trask, B.J.  Comparative sequence analysis of primate subtelomeres.  Submitted.

Rudd, M.K., Friedman, C.F., Parghi, S.S., Linardopoulou, E.V., Hsu, L., and Trask, B.J.  2007.  Elevated rates of sister chromatid exchange at chromosome ends.  PLoS Genetics 3: 319-323.

Doggett, N.A., Xie, G., Meincke, L.J., Sutherland, R.D., Mundt, M.O., Berbari, N.S., Davy, B.E., Robinson, M.L., Rudd, M.K., Weber, J.L., Stallings, R.L., and Han, C.  2006.  A 360 kb interchromosomal duplication of the human HYDIN locus.   Genomics 88: 762-771.

Lam, A.L., Boivin, C.D., Bonney, C.F., Rudd, M.K., and Sullivan, B.A.  2006.  Human centromeric chromatin is a dynamic chromosomal domain that can spread over noncentromeric DNA.  PNAS 103: 4186-4191.

Rudd, M.K., Wray, G.A., and Willard, H.F.  2005.  The evolutionary dynamics of alpha satellite.  Genome Research 16: 88-96.

Grimes, B.R., Babcock, J., Rudd, M.K., Chadwick, B.P., and Willard, H.F.  2004.  Assembly and characterization of heterochromatin and euchromatin on human artificial chromosomes.  Genome Biology 5: R89.

Rudd, M.K. and Willard, H.F.  2004.  Analysis of the centromeric regions of the human genome assembly.  Trends in Genetics 11: 529-533. 

Rudd, M.K., Mays, R.W., Schwartz, S., and Willard, H.F.  2003.  Human artificial chromosomes with alpha satellite-based de novo centromeres show increased frequency of nondisjunction and anaphase lag.  Molecular and Cellular Biology 23: 7689-7697.

Schueler, M.G., Higgins, A.W., Rudd, M.K., Gustashaw, K., and Willard, H.F.  2001.  Genomic and genetic definition of a functional human centromere.  Science 294: 109-115.